On Thursday night, Sanders was called out by many media outlets for looking "positively miserable" while Hillary Clinton thanked him during her speech during the Democratic National Convention.

"Bernie, your campaign inspired millions of Americans, particularly the young people who threw their hearts and souls into our primary," Clinton said as the camera cut to a stoic Sanders. "You've put economic and social justice issues front and center, where they belong."

On HBO's 'Real Time' Friday night, Bill Maher brought up the incident, noting the Vermont senator "didn't look too happy" and compared him to "a husband sitting [outside] the waiting room while the wife tries on clothes."

Maher contrasted Sanders' emotionless reaction to Clinton's compliment to a moment that happened on Tuesday during the DNC. During the convention's roll call vote, Sanders began to cry when his brother, Larry, took the microphone and offered a short but impactful message about their parents, Eli Sanders and Dorothy Glassberg Sanders.

"They did not have easy lives, and they died young," a teary-eyed Larry Sanders said. "They loved the New Deal of Franklin Roosevelt, and would be especially proud that Bernard is renewing that vision."

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"What my brother reminded me of is how my parents, who died young, might have felt at that moment," Sanders told Bill Maher on Friday's HBO's 'Real Time,' explaining he and his brother grew up in a family that didn't have a whole lot of money.

"My father dropped out of high school, my mother never went to college," Sanders revealed. "I think the idea that their son might be a serious candidate for president of the United States is nothing they ever would've dreamed of. That's what struck a chord in me."

Maher also pressed the 74-year-old Sanders on the idea of running for president again, saying he disagreed with MSNBC host Chris Matthews that people in their 70s are "just dribbling down to the last few days of their life."

"Four years from now is a long time," Sanders replied, noting he planned on running for re-election to his Senate seat in Vermont in two years."

"You're not too old to run again," Maher repeated. "Think about it."

Watch the full interview: