Drexel and Penn duked it out in a nonconference women's basketball game at the Daskalakis Athletic Center yesterday. Then the Dragons started landing knockout blows from long distance.

Drexel rode a three-point shooting spree, particularly from sophomore Alison Lupariello, to a 60-41 victory.

Lupariello, a native of Cincinnati, hit all four of her three-point attempts in the second half. At the break, the score was tied at 26.

Overall, Drexel (3-6) connected on 12 of 25 attempts from beyond the arc to help offset a huge 39-22 rebounding edge by Penn (3-6).

The win marked the first time that Drexel's men and women beat Penn in the same season.

"The bottom line is we made too many turnovers, especially at the start of the second half," Penn coach Pat Knapp said.

Penn committed 25 turnovers to 12 by Drexel, which outscored the Quakers by 29-7 off miscues.

The women's teams are so neighborly that they spend hours playing pickup games against each other at the Palestra or a few blocks away at Drexel.

"I told our players, 'You girls know each other so well, we don't need any scouting reports, we just have to worry about ourselves,' " Drexel coach Denise Dillon said. " 'Set the tempo on defense and run our offense and see if we can get a lot of open looks.' "

Gabriela Marginean scored 16 points for Drexel, while all 12 of Lupariello's points came off threes. Narissa Suber, who made three treys, added 11 points.

Sarah Bucar was the only Penn player in double figures, with 10 points.

"We see them year-round," Lupariello said of the rivalry. "We just stayed with the same strategy. We knew they were giving us open [shots], so we had to just keep shooting confidently."

Drexel senior Stacy McCullough, a Central Bucks East graduate, gave a solid performance at point guard in place of Andrea Peterson, who suffered a season-ending knee injury playing against Army last month.

The former Archbishop Carroll star had surgery Wednesday, and Drexel will appeal to the NCAA to get the senior another year of eligibility.

Contact staff writer Mel Greenberg at 215-854-5725 or mgreenberg@phillynews.com. Read his blog at go.philly.com/womhoops.