Yankees pitcher Michael Pineda was ejected in the second inning of Wednesday's New York-Boston game after umpires found a foreign substance on his neck.

Pineda's ejection came 13 days after the right-hander had brown goo on the palm of his pitching hand during a 4-1 win over Boston at Yankee Stadium.

That sparked a debate about pitchers' use of sticky substances to get a better grip in cool weather. The game time temperature Wednesday was 50 degrees.

Boston manager John Farrell didn't challenge Pineda's use of the substance on April 10.

But with two outs, no runners, and a 1-2 count on Grady Sizemore at Fenway Park, Farrell talked to plate umpire Gerry Davis, who went to the mound. Davis touched the right side of the pitcher's neck with his index finger, then ejected Pineda.

Before the game, Farrell said, "I would expect if it's used, it's more discreet than last time."

Pineda left with the Yankees trailing 2-0, and the Red Sox went on to win, 5-1.

Rule 8.02(b) says a pitcher shall not "have on his person, or in his possession, any foreign substance. For such infraction of this section the penalty shall be immediate ejection from the game. In addition, the pitcher shall be suspended automatically."

In 2012, Rays reliever Joel Peralta received an eight-game suspension for having pine tar on his glove.

Man of the hour

Backup catcher Hector Sanchez hit two of San Francisco's six homers, including a grand slam in the 11th inning that gave the Giants a thrilling 12-10 victory over the Rockies in Colorado.

With the Giants on the verge of being swept in a three-game series at Coors Field for the first time in 12 years, Sanchez drove a fastball from Chad Bettis (0-1) into the bushes behind center field. He also hit a solo homer in the eighth.

Birthday bashing

The Chicago Cubs marked Wrigley Field's 100th birthday in dramatic fashion, allowing the Arizona Diamondbacks to rally for five runs in the ninth inning and a 7-5 victory.

After an error by shortstop Starlin Castro, Martin Prado hit a two-run single off Pedro Strop (0-2), Miguel Montero had a tying single against James Russell, and Aaron Hill followed with a two-run triple off Justin Grimm.