Mike Adams was activated off the disabled list after Monday's game with the Braves.
Adams had shoulder surgery on July 31. But he hasn't pitched in a big-league game in almost 10 months.
Adams' last appearance came on June 19, 2013.
"It's going to be a good feeling, I know that," Adams said.
Adams made his final rehab appearance on Saturday at Triple A Lehigh Valley. He allowed a run on two hits; he also struck out a batter.
"I didn't have my best stuff," Adams said, "but overall I got through it healthy and I felt all right."
Adams signed a 2-year, $12 million deal as a free agent before the 2013 season to be the Phillies' setup man in front of closer Jonathan Papelbon. He could be eased back into regular work initially, according to manager Ryne Sandberg.
"We'll use him smartly to start with," Sandberg said of Adams, who pitched on back-to-back days five times in 28 games last season. "We'll go from there and see how he rebounds. See how he looks, see how he pitches, see how he looks the next day."
Tony Gwynn Jr. made his fourth straight start in centerfield. Sandberg said Ben Revere, who had sore ribs over the weekend, was healthy to play, but he decided to stick with the same lineup to "keep the momentum going."
The Phillies won each of the first three games Gwynn started in center.