Tom Izzo was somber after his team's first setback of the season.
J.P. Tokoto had 12 points and a career-high 10 rebounds to help North Carolina beat top-ranked Michigan State, 79-65, Wednesday night in East Lansing, Mich.
"One of the more disappointing performances of my career here," Izzo said. "From the jump ball, they kind of took it to us."
The Tar Heels were in control from the start, never trailed, and used a 12-1 run to take a 65-52 lead with 6 minutes, 2 seconds remaining.
"Michigan State did not want it that much more than we did," North Carolina coach Roy Williams said.
Izzo agreed. "We looked soft," the hard-nosed coach said.
Kennedy Meeks scored 15 points for North Carolina, and Brice Johnson had 14 off the bench.
North Carolina (5-2) has been talented enough to defeat the No. 1 Spartans (7-1) and then-No. 3 Louisville this season, but it has lost to Belmont and Alabama-Birmingham.
Rider 89, Monmouth 83 - Anthony Myles collected a career-high 28 points, as the Broncs (2-4 overall) held on to defeat the host Hawks (3-5) in the Metro Atlantic Athletic Conference opener for both in West Long Branch, N.J.
George Mason suspended Anali Okoloji after the junior forward stepped on an opposing player during a loss to South Florida on Wednesday. He will miss Sunday's game against Oklahoma.
Penn 70, LIU Brooklyn 57 -
A strong second half lifted the Quakers (2-2) over the visiting Blackbirds (0-7). Penn's Kara Bonenberger finished with 13 points and a team-high eight rebounds and three assists.
La Salle 73, William and Mary 59 - Leeza Burdgess scored a career-high 20 points to lead the Explorers (3-4) past the Tribe (1-6) in Williamsburg, Va. Siobhan Beslow set a new career mark with 11 points, and Micahya Owens added 19 for La Salle.
Haverford 49, Franklin and Marshall 38 - The Fords are 6-0 overall and 4-0 in the Centennial Conference after beating the visiting Diplomats (2-5, 1-3). Shannon Smith paced the hosts with five blocked shots, while Elizabeth Lynch came up with six steals.
Johns Hopkins 72, Swarthmore 61 - Elle Larsen scored 22 points, and Katie Lytle added 19, but the Garnet (3-4, 0-4 Centennial) fell to the Blue Jays (6-2, 5-0).