ORCHARD PARK, N.Y. - Veteran Mario Williams and third-string newcomer Bacarri Rambo made for an unlikely Buffalo Bills defensive duo.

They played havoc with Aaron Rodgers and the Green Bay Packers in a 21-13 victory on Sunday.

Rambo, filling in after backup safety Duke Williams was hurt early in the third quarter, intercepted Rodgers on consecutive drives in the second half.

Williams helped seal the victory when he forced Rodgers to fumble into the end zone, which led to a safety when running back Eddie Lacy picked up the ball with 1 minute, 51 seconds left.

The play was whistled dead at that point because only Rodgers was allowed to advance the ball with less than two minutes remaining.

Marcus Thigpen scored on a 75-yard punt return and Dan Carpenter hit all three field goal attempts, including a 51-yarder in the second half to help keep Buffalo (8-6) in the AFC playoff picture. The Bills have posted their first eight-win season since going 9-7 in 2004.

The Packers (10-4) had a five-game winning streak snapped and squandered an opportunity to get closer to their sixth straight playoff berth.

Rodgers finished 17 of 42 for 185 yards and two interceptions. It was an unlikely meltdown for Rodgers and the offense that entered the game on a tremendous roll.

Rodgers had been picked off just three times this season, and none since throwing two in Green Bay's last loss, 44-23, at New Orleans on Oct. 26.

The Packers were limited to Lacy's 1-yard TD run and two field goals by Mason Crosby.

This from a team coming off a 43-37 win over Atlanta that had outscored its last five opponents by 210-113. Rodgers combined for 1,580 yards passing with 16 touchdowns and no turnovers in his previous five games.

It came to a halt against a dominating Bills defense that last week contained Peyton Manning. Despite a 24-17 loss at Denver, the Bills ended Manning's 51-game streak with a touchdown pass.

Bills 21, Packers 13

Green Bay 3 7 0 3 – 13

Buffalo 7 3 6 5 – 21

First quarter

GB–FG Crosby 45, 4:27.

Buf–Thigpen 75 punt return (Carpenter kick), 2:09.

Second quarter

GB–Lacy 1 run (Crosby kick), 14:14.

Buf–FG Carpenter 27, 8:04.

Third quarter

Buf–FG Carpenter 51, 9:21.

Buf–FG Carpenter 35, 4:18.

Fourth quarter

Buf–FG Carpenter 48, 9:23.

GB–FG Crosby 34, 4:51.

Buf–Robey safety, 1:51.

A: 70,214.

GB   Buf

First downs 21   13

Total Net Yards 333   253

Rushes-yards 25-158   33-113

Passing 175   140

Punt Returns 2-5   2-75

Kickoff Returns 1-8   2-27

Interceptions Ret. 1-0   2-44

Comp-Att-Int 17-42-2   14-27-1

Sacked-Yards Lost 1-10   3-18

Punts 6-42.8   6-40.3

Fumbles-Lost 1-0   1-0

Penalties-Yards 9-70   10-75

Time of Possession 27:02   32:58

INDIVIDUAL STATISTICS

Rushing: Green Bay, Lacy 15-97, A.Rodgers 3-27, Starks 4-19, Cobb 3-15. Buffalo, Jackson 20-71, Dixon 6-26, B.Brown 4-20, Orton 3-(minus 4).

Passing: Green Bay, A.Rodgers 17-42-2-185. Buffalo, Orton 14-27-1-158.

Receiving: Green Bay, Cobb 7-96, Nelson 5-55, Lacy 2-11, Starks 1-10, Quarless 1-7, D.Adams 1-6. Buffalo, Jackson 3-27, Chandler 2-22, Woods 2-22, Smith 2-1, B.Brown 1-40, Watkins 1-28, Gray 1-7, Hogan 1-6, Dixon 1-5.

Missed Field Goals: Green Bay, Crosby 53 (BK).