Harvard's Tommy Amaker is more than familiar with North Carolina from his days as a standout player and assistant coach at Duke, although that won't make it any easier going against the Tar Heels in the second round of the NCAA tournament.

The 13th-seeded Crimson are in the tourney for the fourth straight season as Ivy League champions and have won their opening game the last two seasons. It gives them confidence they can be successful on this stage, regardless of how much it might mean to their coach to knock off an old rival from the Atlantic Coast Conference.

"Honestly, I try to keep my history out of it. It's not about me," Amaker said, looking ahead to Thursday's West Regional matchup against the fourth-seeded Tar Heels at Jacksonville Veterans Memorial Arena in Jacksonville, Fla.

"It certainly is about what these kids have accomplished in our program and what we've done over the last number of years and how excited I am for them," the coach added.

Wofford vs. Arkansas. Arkansas didn't know anything about Wofford when the NCAA tournament pairings were announced Sunday night.

Three days later, the Razorbacks are still in the dark.

"Our team really hasn't [gone] over them yet," said star forward Bobby Portis, the Southeastern Conference player of the year. "Coach just always tries to preach we aren't worried about the other team, like, our team is just worried about what we do."

Xavier vs. Mississippi. Forgive Stefan Moody, M.J. Rhett and their Mississippi teammates for looking and feeling a little drained Wednesday.

After all, they played a physically grueling First Four game in Dayton, Ohio, on Tuesday night, flew three hours to Jacksonville in the middle of the night, got a few hours' sleep, then arrived at the arena for a shootaround about 18 hours after wrapping up the come-from-behind victory against Brigham Young.

Now, the 11th-seeded Rebels hope to catch a second wind before playing sixth-seeded Xavier (21-13) on Thursday.

Ohio State vs. VCU. Do-it-all freshman D'Angelo Russell will likely be one of the top picks in the NBA draft this summer and inherit all the expectations that come with it.

First, he'll find out whether he can handle a different kind of pressure: playing in the NCAA tournament against a team that tries to create chaos.

Russell will lead Ohio State (23-10) against vigorous Virginia Commonwealth (26-9) in the round of 64 on Thursday, and even the Rams are eager to see what he can do on college basketball's big stage.