The Eagles will likely see a familiar face lined up opposite them Monday night when they play the New York Giants.

The NFC East rival is without rookie quarterback Daniel Jones for at least the next two days of practice because of a right high-ankle sprain, head coach Pat Shurmur said Wednesday in a team statement. It’s unlikely Jones will be ready for the prime-time game at Lincoln Financial Field.

Shurmur, who was the Eagles’ offensive coordinator from 2013 to 2015, said the rookie out of Duke won’t need surgery but could be done for the season.

With Jones out, the 2-10 Giants would turn to veteran quarterback Eli Manning. Manning was benched in favor of Jones in Week 3 and has been the backup since. Manning is 10-20 against the Eagles, but the Birds’ defense might prefer to see Jones under center.

Jones, the sixth overall pick in April’s NFL draft, leads the league in fumbles this season with 15. The 22-year-old is coming off his worst game of the year, throwing three interceptions in a 31-13 loss to the Green Bay Packers at MetLife Stadium on Sunday.

Eagles defensive coordinator Jim Schwartz said the defense will prepare differently for the Giants’ offense with Manning under center, primarily spending less time game-planning for mobility at the quarterback spot.

Jones has run for 241 yards, averaging 6.2 yards per carry. Manning has run for 218 yards since 2011, averaging 1.4 yards per attempt.

“They’re different," Schwartz said. "Jones had been running some zone read and had made some scramble plays. So, scramble was a part of [the game plan], and zone read was a part of it, and that kind of stuff. Eli, that’s not a huge part of his game.”

Jones has thrown 18 touchdowns to 11 interceptions in 11 games. Manning has thrown two touchdowns and two picks in just 89 attempts.

According to Pro Football Focus, Jones has averaged 2.73 seconds between the snap and his throws, the third highest among quarterbacks with more than five games played this season. He’s been pressured accordingly, being rushed on 43% of his drop-backs, the highest among those signal-callers.

Manning averaged 2.47 seconds in the pocket last season and figures to continue getting the ball out quickly, Schwartz said.

“Jones had been holding the ball a little bit in the pocket,” Schwartz said. “We know Eli’s not going to hold it; the ball’s going to come out pretty quick.”

The Eagles have a lot of experience playing against Manning. The 38-year-old quarterback has lost five straight games at the Linc since 2014 and is 6-9 when traveling to Philadelphia.

“We’ve played Eli for a while now,” Eagles linebacker Kamu Grugier-Hill said. “But, at the same time, he’s still a vet; he’s still a two-time Super Bowl MVP. He’s still a great quarterback, and you have to prepare. ... Eli is dangerous in his own ways, so you just have to adjust to that."