Trent Cole fractured a bone in his hand against the Cowboys on Sunday night, an NFL source said.
It's unclear if the Eagles outside linebacker will need season-ending surgery. Even if he doesn't, Cole would be a long shot to play against the Redskins on Sunday.
Cole was unavailable for comment after the game. Eagles coach Chip Kelly said he didn't have an update on Cole at his Monday news conference.
If Cole is sidelined, Brandon Graham would start at the "Predator" outside linebacker spot opposite Connor Barwin. Bryan Braman would be the third man in the rotation. The Eagles moved top draft pick Marcus Smith to inside linebacker in September and he has stayed there since, although he has hardly played.
Cole is the Eagles' longest-tenured player along with guard Todd Herremans, who suffered a season-ending biceps injury in November. Cole is under contract for next season, but if would be difficult for the Eagles to bring him back at his $10-plus million salary.