Insider Transactions

Securities trades recently reported to the Securities and Exchange Commission by officers, directors, and principal shareholders of corporations based or having sizable employment in the Philadelphia area. Titles are as reported to the SEC.

Winston J. Churchill Jr.

, director, sold 882 shares from $4.13 to $4.16 Dec. 15 and 16, and now indirectly holds 19,250 shares.

Arnold Wayne Donald

, director, sold 2,000 shares at $33.05 Dec. 15 and now directly holds 55,997 shares.

Fred V. Frigo

, officer, sold 6,764 shares from $38.00 to $39.37 Dec. 12 to 16 and now directly holds 49,600 shares.

Austin W. Marxe

, beneficial owner, sold 1,295,000 shares at 38 to 40 cents Dec. 9 to 13 and now indirectly holds 9,828,250 shares.

Tek Chee Mak

, officer, sold 2,704 shares at $8.96 Dec. 15 and now directly holds 106,502 shares.

Charles J. Salmons, officer, sold 1,475 shares at $8.96 Dec. 15 and now directly holds 33,764 shares.

Michael T. Hagan

, chief investment officer, sold 10,000 shares at $29.27 Dec. 13 and now directly holds 64,689 shares.

Vito S. Pantilione

, chief executive officer, bought 200 shares at $5.35 Dec. 19 and now directly holds 104,106 shares.

Harold Cramer

, director, sold 15,000 shares at $35.69 Dec. 15 and now directly holds 82,195 shares.

14159 Capital Gp L.L.C.

, beneficial owner, bought 7,828 shares at $27.29 Dec. 14 and now indirectly holds 303,264 shares.

BakerBiotech Capital Gp L.L.C., beneficial owner, bought 50,566 shares at $27.29 Dec. 14 and now indirectly holds 1,966,090 shares.

Baker Bros. Life Sciences Capital Gp L.L.C., beneficial owner, bought 291,706 shares at $27.29 Dec. 14 and now indirectly holds 9,840,470 shares.

Colin Broom, officer, sold 90,000 shares at $23.50 to $25.50 Dec. 12 to 14 and now directly holds 19,439 shares.

Jennifer W. Davis

, director, bought 279 shares at $34.84 to $36.14 Dec. 14 and 15 and now directly holds 3,205 shares.