Insider Transactions

Securities trades recently reported to the Securities and Exchange Commission by officers, directors, and principal shareholders of corporations based or having sizable employment in the Philadelphia area. Titles are as reported to the SEC.

James F. Cleary Jr.

, officer, bought 1,000 shares at $102.54 on March 9, and now directly holds 1,000 shares.

Guillaume Marie Rutten

, officer, sold 15,000 shares at $9.83 on March 5; the holdings were not reported.

Michael S. Castleman

, chief financial officer, bought 5,000 shares at $14.25 to $14.35 on March 9, and now directly holds 7,500 shares.

David M. Cordani

, chief executive officer, sold 101,856 shares at $121.02 on March 6, and now directly holds 281,634 shares.

Nicole S. Jones, general counsel, sold 10,935 shares at $121.31 on March 6, and now directly holds 15,601 shares.

Matthew G. Manders, officer, sold 15,263 shares at $120.95 on March 6, and now directly holds 50,827 shares.

Thomas A. McCarthy, chief financial officer, sold 4,488 shares at $120.74 on March 4, and now directly holds 63,368 shares.

Jason D. Sadler, officer, sold 22,376 shares at $120.30 to $121.14 on March 6, and now directly holds 27,600 shares.

Arthur R. Block

, general counsel, sold 1,811 shares at $60.02 on March 10, and now directly holds 28,836 shares.

Camille Farhat

, officer, sold 40,438 shares at $87.02 on March 9, and now directly holds 8,650 shares.

Brian Lortie, officer, sold 5,800 shares at $85.35 on March 4, and now directly holds 16,784 shares.

Caroline Berry Manogue, officer, sold 42,033 shares at $87.78 on March 5, and now directly holds 43,100 shares.

Matthew B. Scott

, officer, sold 2,913 shares at $26.50 to $26.95 March 6 to March 10, and now directly holds 26,468 shares.

Richard U. De Schutter

, board chairman, sold 40,000 shares at $91.68 to $92.19 on March 5, and now directly holds 92,290 shares.

Eric H. Siegel, general counsel, sold 13,333 shares at $90.00 on March 5, and now directly holds 3,355 shares.

Life Sciences Opportunities Fund II L.P.

, beneficial owner, sold 2,000,000 shares at $9.95 on March 5, and now directly and indirectly holds 9,851,860 shares.

Peter Fasolo

, officer, sold 115,307 shares at $102.40 on March 5, and now directly holds 32,588 shares.

Dennis R. Glass

, chief executive officer, sold 576,471 shares at $59.00 to $60.19 on March 6, and now directly holds 677,478 shares.

Mark E. Konen, officer, sold 11,904 shares at $56.73 to $57.75 on March 10, and now directly holds 81,714 shares.

Douglas N. Miller, officer, sold 3,471 shares at $59.19 on March 9, and now directly holds 12,341 shares.

Patrick S. Pittard, director, sold 1,945 shares at $58.28 on March 5, and now directly holds 18,865 shares.

Stuart J. Black

, officer, sold 2,500 shares at $40.23 on March 11, and now directly holds 5,168 shares.

Joseph A. Berquist

, officer, sold 2,342 shares at $80.38 to $82.00 on March 6, and now directly holds 15,109 shares.

Edward J. Hoffman

, general counsel, sold 3,290 shares at $16.07 on March 9, and now directly holds 27,411 shares.

Julie A. Dobson

, director, sold 12,498 shares at $18.26 on March 9, and now directly holds 16,332 shares.

Dennis J. McGonigle

, officer, sold 15,000 shares at $42.53 to $43.01 March 3 to March 4, and now directly holds 652,034 shares.

Alfred P. West Jr., beneficial owner, sold 55,339 shares at $42.29 to $43.28 March 2 to March 6, and now directly holds 12,154,700 shares.

Thomas J. Lynch

, chief executive officer, sold 53,359 shares at $71.92 on March 9, and now directly holds 367,564 shares.