Anne LaCour Neeb, executive director of the state's Gaming Control Board, is resigning her post.
Neeb made the announcement at the board's meeting in Harrisburg this afternoon. She cited "personal and family" reasons.
"I need to direct my attention to some family matters that need to be taken care of," Neeb said.
She added: "I am very happy and very proud of the accomplishments of this agency."
Neeb, who earns a salary of $180,000, steps down effective June 6. Frank T. Donaghue, the board's chief counsel, will serve as acting executive director until the board finds a permanent replacement.
The board has recently drawn criticism from lawmakers and others about how it issued licenses for slots parlors.
One of the licensees the board approved in 2006 - Scranton businessman Louis A. DeNaples - was charged earlier this year with perjury for allegedly lying to state gaming investigators while vying for a license.
DeNaples is fighting the charges.