PESHAWAR, Pakistan - A U.S. drone strike has killed a senior al-Qaeda leader in Pakistan's tribal region near the Afghan border, Pakistani intelligence officials said, in the latest blow to the Islamic militant network.

Sheikh Khalid bin Abdel Rehman al-Hussainan, who was also known as Abu Zaid al-Kuwaiti, was killed when missiles slammed into a house Thursday near Mir Ali, one of the main towns in the North Waziristan tribal area, the officials said. They spoke on condition of anonymity because they were not authorized to talk to the media.

Kuwaiti appeared in many videos released by al-Qaeda's media wing, Al-Sahab, and was presented as a religious scholar for the group.

Earlier this year, he replaced Abu Yahya al-Libi, al-Qaeda's second in command, who was killed in a U.S. drone strike in North Waziristan in June, the intelligence officials said. Libi was a key religious figure within al-Qaeda and a prominent militant commander. Kuwaiti appeared to be a less prominent figure and was not part of the U.S. State Department's list of most wanted terrorist suspects, as Libi had been.

Covert CIA drone strikes have killed a series of senior al-Qaeda and Taliban leaders in Pakistan's tribal region over the last few years. The attacks are controversial because the secret nature of the program makes it difficult to determine how many civilians are being killed.

On Sunday, four drone-launched missiles blew apart a house near Miran Shah, another main town in North Waziristan, killing three suspected militants, intelligence officials said. North Waziristan has become the main hub for al-Qaeda and Taliban militants in Pakistan.

Pakistani officials often criticize such strikes as a violation of the country's sovereignty, which has helped make them extremely unpopular in the country. But senior Pakistani officials are known to have cooperated with strikes.

Kuwaiti's wife and daughter were wounded in Thursday's drone attack, according to the intelligence officials. His wife died a day later at a hospital in Miran Shah.

A Pakistani Taliban commander who frequently visits North Waziristan told the Associated Press by telephone that he met some Arab fighters Saturday who were "very aggrieved." They told him they lost a "big leader" in a drone strike, but would not reveal his name. The commander spoke on condition of anonymity for fear of revealing his identity to the government.