Penn will host Boston University in the first round of the NCAA women's lacrosse tournament on Sunday at 2 p.m.
Northwestern (17-1) received the tournament's No. 1 seed, followed by No. 2 Duke (14-3) and No. 3 Virginia (16-3).
The Quakers' fourth seed assures them of homefield advantage throughout the tournament since the national semifinals and title game will be held at Franklin Field (May 25 and 27).
The game against Boston University, however, will be held at Rhodes Field, home of Penn's soccer team, because of a graduation ceremony taking place at Franklin Field.
Penn, which won the Ivy League title, has a 13-1 record and is ranked No. 2 in the nation. The Quakers' only loss was to Northwestern in their fourth game of the season.
Boston University (13-5), the American East champion, is ranked No. 22 and has won nine consecutive games.
The game will be the first-ever meeting between the Quakers and Terriers. Penn's potential second-round matchup would be the winner of fifth-seed Maryland (15-3) and Yale (13-3).