Here are some key matchups that may determine Sunday's game.
Eagles tackles Jason Peters and King Dunlap vs. Giants defensive ends Osi Umenyiora and Justin Tuck
The Giants' ends have a combined 181/2 sacks and 14 forced fumbles. Tuck brought Michael Vick down three times in the first game, on Nov. 21. Peters and Dunlap - or Winston Justice, if healthy - will have the tough task of keeping them away from their quarterback.
Eagles MLB Jamar Chaney vs. Giants RB Brandon Jacobs
Chaney gets his first career start against one of the toughest running tandems in the league, starting with Jacobs, who is listed as four inches taller and 22 pounds heavier than the Eagles rookie. Chaney will have to make play calls and probably cover tight ends, but his biggest job may be bringing down Jacobs.
Eagles RB LeSean McCoy vs. Giants LB Michael Boley
McCoy has gained 120 total yards or more in each of the last four games, including a 111-yard rushing day against the Giants. His 50- and 40-yard runs in the fourth quarter changed that game. Boley is the top tackler in the Giants' front seven, perhaps their best chance to slow down Shady.
Eagles QB Michael Vick vs. Giants safety Deon Grant
The Giants threw Grant, and sometimes Antrel Rolle, into their pass rush when these teams last met, adding defensive back speed into the brawn chasing Vick. It often worked. Vick was contained for much of the game. Does the elusive quarterback have a counter this week?
Eagles WRs DeSean Jackson and Jeremy Maclin vs. Giants CBs Corey Webster and Terrell Thomas
The Giants seem poised to attack Vick. The Eagles do some of their best work against the blitz, when fewer defenders are left back to fence in their playmakers. Jackson went for 210 yards against the Cowboys. Maclin burned the Giants for 120 yards in the first meeting. The Eagles will need at least one of them to get loose this week.