Here are some key matchups that may determine Sunday's game.
The Giants' ends have a combined 181/2 sacks and 14 forced fumbles. Tuck brought Michael Vick down three times in the first game, on Nov. 21. Peters and Dunlap - or Winston Justice, if healthy - will have the tough task of keeping them away from their quarterback.
Chaney gets his first career start against one of the toughest running tandems in the league, starting with Jacobs, who is listed as four inches taller and 22 pounds heavier than the Eagles rookie. Chaney will have to make play calls and probably cover tight ends, but his biggest job may be bringing down Jacobs.
McCoy has gained 120 total yards or more in each of the last four games, including a 111-yard rushing day against the Giants. His 50- and 40-yard runs in the fourth quarter changed that game. Boley is the top tackler in the Giants' front seven, perhaps their best chance to slow down Shady.
The Giants threw Grant, and sometimes Antrel Rolle, into their pass rush when these teams last met, adding defensive back speed into the brawn chasing Vick. It often worked. Vick was contained for much of the game. Does the elusive quarterback have a counter this week?