INDIANAPOLIS - Reggie Wayne will always remember last night's catch.

The man with the expiring contract caught a 1-yard touchdown pass from Dan Orlovsky with 19 seconds left, giving the Colts their only lead of the game in a 19-16 victory over AFC South champion Houston.

It's the second straight win for the Colts (2-13), who will have to fight off St. Louis and Minnesota for the No. 1 overall draft pick. Orlovsky, who played the last two seasons with Houston, also won his second straight game after losing his first nine NFL starts.

Houston was in a position to come to Indianapolis and simply tune up for the postseason.

Not a chance.

The Texans settled for two field goals in the red zone, didn't convert a third down until getting a lucky bounce late in the fourth quarter, its running game was stymied late and the defense helped the Colts with three penalties on the decisive drive.

Houston (11-4) is now 0-10 in Indianapolis and still hunting for a first-round bye. The Texans still haven't scored more than 20 points in a game since Nov. 27.

Brian Cushing broke through the line on the game's first play, sacking Orlovsky and stripping the ball. Arian Foster ran for 8 yards on the next play, then scored on a 9-yard burst off the left side to give Houston a 7-0 lead. Nobody got into the end zone again until Orlovsky took the Colts 78 yards in the final 2 minutes and finally hooked up with Wayne, who outmaneuvered a defender for the winning score.

In between, Neil Rackers and Adam Vinatieri traded field goals.

Before the game, Colts owner Jim Irsay said that if quarterback Peyton Manning plays football next season, it will be in Indianapolis.

Irsay said Manning is progressing from his neck injury, that his throwing arm is getting stronger and that his greatest concern is Manning's overall health. But if Manning can play in 2012, Irsay says he will not try to slash costs by getting rid of the league's four-time MVP.

Irsay said the Colts would take Manning's successor in April's NFL draft if the right quarterback is available. Indy is the front-runner for the No. 1 overall pick and could take Stanford's Andrew Luck.