SEATTLE - Russell Wilson threw four touchdown passes to move into second place for touchdown passes by a rookie, and Marshawn Lynch scored twice as Seattle clinched a spot in playoffs spot by routing San Francisco before a rocking audience.

Wilson threw TDs to Lynch, Anthony McCoy, and two in the second half to Doug Baldwin to give him 25 for the season, one shy of Peyton Manning's record of 26. Lynch added 111 yards rushing and a 24-yard TD run on Seattle's opening drive that set the tone.

Richard Sherman returned a blocked field goal 90 yards for a touchdown and added an interception for the Seahawks (10-5).

Colin Kaepernick and the 49ers (10-4-1) struggled with the deafening noise echoing around CenturyLink Field, making for a miserable 49th birthday for 49ers coach Jim Harbaugh.

Seahawks 42, 49ers 13

San Francisco 0 6 0 7 – 13

Seattle 14 14 7 7 – 42

First quarter

Sea–Lynch 24 run (Hauschka kick), 13:48.

Sea–Lynch 9 pass from Wilson (Hauschka kick), 4:26.

Second quarter

Sea–Sherman 90 blocked field goal return (Hauschka kick), 14:05.

SF–FG Akers 33, 10:19.

Sea–McCoy 6 pass from Wilson (Hauschka kick), 1:58.

SF–FG Akers 54, :31.

Third quarter

Sea–Baldwin 4 pass from Wilson (Hauschka kick), 3:22.

Fourth quarter

Sea–Baldwin 6 pass from Wilson (Hauschka kick), 7:02.

SF–Walker 18 pass from Kaepernick (Akers kick), 1:40.

A: 68,161.

SF   Sea

First downs 17   22

Total Net Yards 313   346

Rushes-yards 19-82   39-176

Passing 231   170

Punt Returns 0-0   2-17

Kickoff Returns 7-176   2-63

Interceptions Ret. 1-2   1-0

Comp-Att-Int 19-36-1   15-22-1

Sacked-Yards Lost 1-13   1-1

Punts 3-51.7   1-41.0

Fumbles-Lost 2-1   0-0

Penalties-Yards 6-58   4-45

Time of Possession 24:51   35:09

INDIVIDUAL STATISTICS

Rushing: San Francisco, Kaepernick 7-31, Gore 6-28, James 4-15, Dixon 2-8. Seattle, Lynch 26-111, Turbin 3-38, Wilson 6-29, Robinson 1-1, Flynn 3-(minus 3).

Passing: San Francisco, Kaepernick 19-36-1-244. Seattle, Wilson 15-21-1-171, Rice 0-1-0-0.

Receiving: San Francisco, Crabtree 4-65, Walker 4-54, Moss 3-44, Celek 2-41, James 2-14, Miller 2-(minus 1), V.Davis 1-27, Manningham 1-0. Seattle, Baldwin 4-53, Tate 2-27, Turbin 2-20, Lynch 2-19, Miller 2-15, Kearse 1-17, Rice 1-14, McCoy 1-6.

Missed Field Goals: San Francisco, Akers 21 (BK).