Joel Embiid will miss Tuesday night's game in Salt Lake City as the 76ers kick off a five-game road trip with a game against the Utah Jazz.
The team says that Embiid is out because of "load management" and that the Sixers center will be available for Thursday's game in Sacramento.
In addition, guard Jerryd Bayless injured his left wrist in the fourth quarter of Friday's 121-110 win over Indiana and is out for at least Tuesday's game.
Embiid was a limited participant in Monday's practice. The Sixers had Saturday and Sunday off from practice.
Coach Brett Brown was limited in what he could say about Embiid's time off.
"I follow the instruction of our medical people, and there is completely a thought-out plan why this plan has been recommended," Brown said. "If it requires more information, they will be the ones to explain why they decided to make this recommendation."
Nether Embiid nor Bayless was available for comment.
Ben Simmons practiced, but got a breather when the media were watching the team going full court.
"It's going to be tough, but it means other guys have to step up," Simmons, who is averaging 18 points, 9.8 rebounds and 8.2 assists, said of his teammates' absences. "That is all part of pro sports: People step up, people don't play, and it happened last year with me. I didn't play, and T.J. [McConnell] stepped up."
After missing his first two seasons because of foot surgeries, Embiid appeared in just 31 games last season, playing his final one Jan. 27 before suffering a torn meniscus in his left knee that eventually required surgery. This will be his second game missed this season for the 5-4 Sixers. The other came on Oct. 31 in Toronto, the second of back-to-back games.
In eight games, Embiid is averaging 20.5 points, 10.1 rebounds, 1.4 blocks, 1.4 steals, 3.6 assists and 4.4 turnovers in 27 minutes, 33 seconds of playing time. He missed most of the preseason while recovering from his surgery and has acknowledged not being in 100 percent shape.
The Sixers' backup centers are Amir Johnson, Richaun Holmes and Jahlil Okafor. Holmes made his season debut Friday after missing the first eight games because of a fracture in the radial bone of his left wrist that he suffered Oct. 6.
Against Indiana, Holmes had six points and five rebounds, including four on the offensive glass in 10:11, providing great energy. Johnson is averaging 5.6 points and 5.7 rebounds in 15:44. Okafor has slipped out of the rotation and has appeared in just one game
After Friday's game, X-rays were negative on Bayless' wrist. But based on continued discomfort, he didn't practice Monday and underwent MRI and CT scans. Bayless suffered his injury with 1:53 left when he went through a screen set by Domantas Sabonis and drew an offensive foul.
"In that case, he dipped his shoulder, got through it [the screen], exposed the foul, but along the way, he hurt his wrist," Brown said.
It's the same left wrist that caused Bayless to miss most of last season. He played in just three games because of torn ligaments in his left wrist.
Bayless had played in the first nine games, making seven starts. He is averaging 11 points and shooting 42.2 percent from three-point range in 31:04.