Genk vs. Club Brugge

Friday, 2:45 p.m. (ESPN+)

After winning the Belgian Cup a few weeks ago, Mark McKenzie and Genk will try to take another step toward securing a place in next season’s UEFA Champions League qualifying playoffs.

Borussia Dortmund vs. RB Leipzig

Saturday, 9:30 a.m. (ESPN, ESPN Deportes)

Gio Reyna’s Dortmund is a point out from Bundesliga’s last Champions League spot, and would make a big statement in the race with a win over Tyler Adams’ Leipzig. American fans (and ESPN) will hope that both U.S. national team stars start.

» READ MORE: This weekend's Bundesliga schedule

Barcelona vs. Atlético Madrid

Saturday, 10:15 a.m. (beIN Sports, beIN Sports Español)

There have been a lot of games of the season in La Liga, but this one is really it: first-place Atlético hosting third-place Barcelona, with the lead atop the table just two points with four games to go.

On top of that, second-place Real Madrid hosts Sevilla on Sunday (3 p.m., beIN Sports and beIN Sports Español). If Atlético and Sevilla win, the leaders will blow open a big gap. But if Lionel Messi can will Barcelona to another victory, get ready for an all-time sprint to the finish.

» READ MORE: Barcelona's Martin Braithwaite helps launch a North Philly residence for aspiring tech creators of color

Manchester City vs. Chelsea

Saturday, 12:30 p.m. (NBC10, Telemundo, Universo)

Three weeks to the day before these teams meet in the men’s Champions League final, Zack Steffen’s Manchester City (though he’s likely to be on the bench) can clinch the Premier League title with a win over Christian Pulisic’s Chelsea.

This game launches a historic weekend for soccer on U.S. television: it’s the first time that every major broadcast network will air a soccer game. (NBC will air two, this one and Arsenal-West Bromwich Albion Sunday at 2 p.m.) That’s no small feat for a sport that so many people love to hate — especially on a weekend when basketball, hockey, baseball, golf and auto racing also have busy schedules.

Portland Thorns vs. Gotham FC

Saturday, 1 p.m. (CBS3)

The NWSL Challenge Cup final is stacked with stars: Portland’s Crystal Dunn, Becky Sauerbrunn, Christine Sinclair, Lindsey Horan and Sophia Smith against Gotham’s Carli Lloyd, Margaret Purce and Allie Long. And there will be fans in the stands for the 10 a.m. local time kickoff, since Oregon Gov. Kate Brown lifted the COVID-19 emergency order Portland was under at the start of the week.

Even without lifting the order, the game was always likely to stay in Portland. While there was definitely a backup plan in place to use Subaru Park, the odds were slim from the start. But credit to the Union and the NWSL for talking to each other. Here’s hoping they keep in touch, and that the league saw more proof of Philadelphia’s interest in women’s soccer.

JP Dellacamera will have the call of the game, making him the first American soccer broadcaster ever to call games on ABC, NBC, Fox and CBS. He’ll work with analyst Aly Wagner, who’s also his colleague on Fox games, and sideline reporter Marisa Pilla — which means two of the three broadcast team members will come from the Union’s TV crew.

Dave Leno will sub in for Dellacamera for the Union’s game at Chicago, which coincidentally is at the same time on 6ABC.

» READ MORE: Subaru Park was the backup host for the Challenge Cup final if it needed to be moved from Portland

FC Dallas vs. Houston Dynamo

Saturday, 3:50 p.m. (Univision, twitter.com/MLS)

Though Austin FC’s arrival in MLS this year gives the league three teams in Texas, the Texas Derby title still belongs to this matchup. And its season series winner still gets to claim El Capitán, a giant (and functional) howitzer cannon.

Los Angeles Galaxy vs. Los Angeles FC

Saturday, 8 p.m. (Fox, Fox Deportes)

Javier Hernández’s scorching start to the Galaxy’s season came to a halt last weekend in Seattle. But expect him to be plenty fired up for the year’s first edition of the Los Angeles derby. (Call it El Tráfico if you want, but the name has opposition.)

LAFC’s Carlos Vela is questionable due to a quadriceps injury that has sidelined him for the last two games. If he can’t go, we’d once again be deprived of a showdown between MLS’ two biggest stars. Hernández missed all three of the Galaxy’s games against LAFC last year, and hasn’t played against Vela since the 2013 UEFA Champions League group stage. Chicharito was at Manchester United back then, and Vela was at Real Sociedad.

» READ MORE: Want to bet on MLS? Here’s a tip for being better at it.

Chelsea vs. Reading

Sunday, 9:30 a.m. (NBCSN, atafootball.com)

A Chelsea win would give Sam Kerr, Pernille Harder and the Blues the FA Women’s Super League title on the season’s final day. Second-place Manchester City, trailing by two points, will hope sixth-place Reading can spring a huge upset. That would open the door for Sam Mewis and City to snatch the title with a win at West Ham (9:30 a.m., NBCSports.com and atafootball.com).

» READ MORE: Sam Mewis believes she's still fighting for a place on the USWNT's Olympics roster

West Ham United vs. Everton

Sunday, 11:30 a.m. (NBCSN, Peacock, Telemundo)

Let’s give Telemundo some love here too, and do it for a game with big stakes for both teams. West Ham is in fifth place in the Premier League, three points back of fourth-place Chelsea for the last Champions berth. Everton is in eighth, six points back of West Ham.

Let’s also note that this game is on both Peacock and traditional TV channels, which NBC doesn’t do often. Here’s hoping that changes soon.

Inter Miami vs. Atlanta United

Sunday, 1 p.m. (6ABC, ESPN Deportes)

Gonzalo and Federico Higuaín are likely to return for Miami after missing last weekend due to the death of their mother. As for Atlanta, we’ll see if they can bounce back from being bounced from the Champions League by the Union.

» READ MORE: Union’s Jim Curtin gets another win over his critics, including Atlanta United’s Gabriel Heinze

Portland Timbers vs. Seattle Sounders

Sunday, 3 p.m. (6ABC, ESPN Deportes)

Sunday’s MLS doubleheader on ABC is the first ever on the network where games have aired since the league’s inaugural season in 1996. So savor it, and savor the latest edition of the league’s most famous rivalry. Diego Valeri and Portland will try to avoid a Champions League hangover after being eliminated by Club América on Wednesday, while Raúl Ruidíaz will try to keep Seattle in first place in the Western Conference.

» READ MORE: This weekend's MLS TV and streaming schedule