Drexel battled but came up short at the College of Charleston on Saturday.
The Dragons (13-18, 6-12 Colonial Athletic Association) led by one with under five minutes to play, but the Cougars scored five straight and held the lead the rest of the way.
Camren Wynter and Zach Walton each scored 18 points for the Dragons, who will enter the CAA championships in eighth place.
Charleston (17-13, 11-7) was led by Grant Riller’s game-high 25 points.
Zach Walton had a three-pointer bounce around and go in with 4:46 to play to give the Dragons the momentum and a 62-61 lead.