TRENTON - Amid growing concern over drug-resistant superbugs and non-healing wounds that endanger diabetes patients, nature's original antibiotic - honey - is making a comeback.

More than 4,000 years after Egyptians began applying honey to wounds, Derma Sciences Inc., a West Windsor company that makes medicated and other advanced wound-care products, during the fall began selling the first honey-based dressing after it was approved by the Food and Drug Administration.

Called Medihoney, it is made from a highly absorbent seaweed-based material, saturated with manuka honey, a particularly potent type that experts say kills germs and speeds healing. Also called Leptospermum honey, manuka honey comes from hives of bees that collect nectar from manuka and jelly bushes in Australia and New Zealand.

Derma Sciences now sells two Medihoney dressings to hospitals, clinics and doctors in North and South America under a deal with supplier Comvita Ltd., of Tauranga, New Zealand. Derma Sciences hopes to have its dressings in U.S. drugstores within six months, followed by adhesive strips.

Comvita, which controls about 75 percent of the world's supply of manuka honey, sells similar products under its own name in Australia, New Zealand and Europe.

"The reason that Medihoney is so exciting is that antibiotics are becoming ineffective at fighting pathogens," said Derma Sciences chief executive officer Ed Quilty.

Another big advantage, he said, is that the dressings' germ-fighting and fluid-absorbing effects last up to a week, making them convenient for patients being cared for at outpatient clinics or by visiting nurses. They also reduce inflammation and can eliminate the foul odors of infected wounds.

Since getting FDA approval, Medihoney has had sales of $150,000 in 10 weeks, and Quilty plans to nearly double his 15-person sales force in 2008 thanks to the two new Medihoney products.

Honey dressings and gels, as well as tubes of manuka honey, have been gaining in popularity overseas, fueled by scientific reports on their medical benefits and occasional news accounts of the dramatic recovery of a patient with a longtime wound that suddenly healed.

Regular honey can have mild medicinal benefits. A study published Dec. 3 showed it helps to calm children's coughs so they can sleep. But manuka honey is far more potent, research shows.

Robert Frykberg, chief of podiatry at the Veterans Affairs Medical Center in Phoenix, said the Medihoney product has worked on about half the patients with diabetic foot ulcers who have used it.

He said the Medihoney dressing also could prevent the dangerous drug-resistant staph infection known as MRSA from infecting open wounds.

"It's been used on wounds where nothing else will work," said biochemist Peter Molan, a professor at the University of Waikato in New Zealand.

He has found that manuka honey can kill the toughest bacteria even when diluted 10 times and recommends it especially for people with weak immune systems.

"There's more evidence, clinical evidence, by far for honey in wound treatment than for any of the pharmaceutical products" for infection, Molan said. It will not work, however, once an infection gets into the blood. "It's not a miracle."

Some U.S. hospitals and wound-care clinics already are using Medihoney dressings to treat patients with stubborn, infected wounds from injuries or surgical incisions and non-healing pressure ulcers on diabetics' feet, which too often lead to amputations.

Craig Lambrecht, a North Dakota emergency physician who has five children, started using a paste version of Medihoney while serving with the National Guard in Iraq last winter.

At a military clinic for Iraqi children, he used it on patients with severe burns from cooking fuels, open fires and explosions. He said Iraqi families soon preferred the honey over other treatments because it was natural and the honey dressings do not need to be changed as often as traditional ones. The children also healed more quickly and with less complications, he said.

"I would use the Medihoney on burns on my children, as the first choice, without question," he said.