Scientists and other research workers at GlaxoSmithKline P.L.C.'s King of Prussia and Collegeville facilities are getting their pink slips this week.

The British drugmaker, which has a U.S. headquarters in Philadelphia, is cutting 2 percent of its 17,000 global research-and-development employees, or about 350, with about half of them from this region and from the other U.S. headquarters in Research Triangle Park, N.C., spokeswoman Melinda Stubbee said yesterday.

The rest of the cuts will come from facilities in the United Kingdom and Italy.

"For research-and-development specifically, it's about reshaping R&D so we can improve our productivity," she said.

Stubbee said notices went out to employees Tuesday and yesterday. She said that actual termination dates would depend on business needs.

The cuts come as part of plans announced in October by the world's second-largest drugmaker (after Pfizer Inc.) to save $1.37 billion by 2010 by trimming jobs in sales, manufacturing and research.

Meanwhile, Glaxo has opened a facility in China in the last year that houses 400 researchers specializing in neuroscience, Stubbee said. Job cuts in Europe and the United States, she said, were not related to Glaxo's growth in Asia.

Glaxo employs about 5,700 in the Philadelphia area.

Glaxo's chief executive officer has been in the job for less than a month: Andrew Witty took over May 22 from Jean-Pierre Garnier.

Times are rough for Big Pharma. Almost all big pharmaceutical companies have announced layoffs in the last year: GlaxoSmithKline, Wyeth, AstraZeneca P.L.C., Merck & Co. Inc.

All major pharmaceutical companies face the same problems: Their big blockbuster drugs, those with revenue of $1 billion and more, are coming off patent protection and being copied in lower-cost, chemically equivalent versions by makers of generic drugs.

Several of Glaxo's best sellers are losing patent protection this year.

Big Pharma companies do not have enough new drugs ready to go to replace those sales. In addition, it is harder to get new drugs approved by the Food and Drug Administration since Vioxx was withdrawn by Merck after reports of deaths and side effects.

Pharmaceutical companies' own research labs are not producing enough internally, and drug companies are turning for promising products to small biotechnology companies - either acquiring or licensing small biotechs' products.

The news of the cuts follows the disclosure earlier this week that Glaxo plans to restructure its research-and-development operations into smaller units. These units will focus on specific diseases and will be rewarded based on performance.

Glaxo had previously split its research operations into therapeutic areas in a move to boost innovation and bring new drugs into the market. Glaxo now has 157 projects under development, according to its annual report. Of these, 118 are vaccines and 34 are in late-stage development.

Other pharmaceutical companies have also started reorganizing their research-and-development units to reflect new scientific breakthroughs and a more demanding marketplace.

AstraZeneca, the second-largest British drugmaker, spun off part of its gastrointestinal-research operation earlier this year into a new firm called Albireo, following its decision to focus its efforts on respiratory, cancer and infectious diseases.

Glaxo shares closed down 33 cents yesterday at $41.39 on the New York Stock Exchange.

Contact staff writer Jane M. Von Bergen at 215-854-2769 or jvonbergen@phillynews.com.

Inquirer staff writers Linda Loyd and Joseph S. DiStefano contributed to this article, which also contains information from the Associated Press.