Uruguay has won the Copa America 15 times in the tournament's century of existence, more than any other nation.
La Celeste will not come anywhere close to winning their 16th this year.
Venezuela pulled off the Copa America Centenario's biggest upset so far, roughing up Uruguay and pouncing on a spectacular scoring chance to snatch a 1-0 win at Lincoln Financial Field on Thursday night.
The result, paired with Mexico's 2-0 win over Jamaica, eliminated Uruguay.
Venezuela, meanwhile, qualified for the knockout stages after winning two games at a Copa America for the first time ever.
Head coach Rafael Dudamel admitted that the win was "one we wouldn't expect." But other than that, he was in a mood to celebrate.
"The team is like the whole country - happy, proud, excited," he said.
And he played up having pulled off the big win in a city known for backing feisty underdogs.
"We have some Rocky inside of us," Dudamel said.
From the opening whistle, Venezuela set a physical tone. Chief destructor Adalberto Peñaranda flew all over the field, crunching into seemingly every Uruguayan player who came near him. And much to the dismay of the overwhelmingly pro-Uruguay crowd of 23,002, Peñaranada never got anything more than a warning from Argentine referee Patricio Loustau.
While Peñarnada ran free, Uruguay star Edinson Cavani was stranded. For most of the night, his teammates simply couldn't get the ball to him.
There was no question that Uruguay missed star striker Luis Suarez. He has been nursing a hamstring injury, and though he has been fit enough to train he has not been fit enough to play. Head coach Oscar Washington Tabarez insisted Wednesday that Suarez would not play until he is fully healthy, and Thursday he backed it up.
"The player is simply not ready to play," Tabárez insisted.
As Uruguay's play turned sloppy, Veneuzela turned in the dagger. In the 36th minute, Alejandro Guerra looked up from near midfield and spotted Uruguay goalkeeper Fernando Muslera way off his goal line. Guerra went for the long-distance chip, and Muslera could only get far enough back to punch the ball up off the crossbar. The rebound fell to an onrushing Salomon Rondon, who volleyed the bouncing ball into the net.
Uruguay played the second half with more vigor, but only came close to scoring in the final moments. The most astonishing miss came in the 90th minute, when Cavani finally broke free but missed what should have been an easy shot from 12 yards. He couldn't believe it, nor could anyone else in the stadium.