Bishop Joseph P. McFadden, 65, of the Diocese of Harrisburg died Thursday after falling ill while in Philadelphia for a meeting of prelates from Pennsylvania.
A native of Philadelphia and a former auxiliary bishop of the archdiocese, he had been bishop of Harrisburg for less than three years.
His diocese said in a statement the bishop fell ill during the night and was taken to an unindentified Philadelphia hospital, where he died at 7:40 a.m.
Archbishop Charles Chaput said he was "shocked and deeply saddened" by Bishop McFadden's sudden death.
"Bishop McFadden was a native Philadelphian and this diocese was always close to his heart," Chaput said in a statement. "His love for the priesthood was evident in everything that he did. He worked diligently to promote vocations to the priesthood and advance the mission of Catholic education."
Philadelphia City Council held a moment of silence for Bishop McFadden at the start of its meeting Wednesday morning.
Bishop McFadden grew up in West Philadelphia, attending Our Lady of Lourdes elementary school and St. Thomas More High School before going to St. Joseph's University, where he majored om political science.
He graduated from St. Joseph's in 1969 and taught at West Catholic Boys High School, where he coached the basketball team.
Bishop McFadden entered St. Charles Borromeo Seminary in 1976 and was ordained in 1981 by Cardinal John Krol.
In 1982 he was appointed Krol's administrative secretary Krol and held that position from 1982 until 1993, when he was named to be the first president of Cardinal O'Hara High School in Springfield.
In 2001, Bishop McFadden was appointed pastor of St Joseph Parish in Downingtown, where he served until he was appointed an auxiliary bishop of Philadelphia in June 2004.
Six years later, Pope Benedict XVI named Bishop McFadden the 10th bishop of Harrisburg.
Update: This story was corrected to change day of death to Thursday.