Cornerback Asante Samuel has been ruled out for Saturday's crucial game with the Cowboys, the Eagles said Friday.

Samuel injured his hamstring against the Jets and missed the past three practices. Dominique Rodgers-Cromartie will start in his place.

Joselio Hanson will play in the slot in the nickel.

Samuel's absence could be crucial against a Cowboys team that features three significant threats at wide receiver and a big-time tight end.