Eagles vs. 49ers: Predictions, odds, injuries, playoff schedule, and what everyone is talking about

The playoffs are finally here. The Eagles officially kick off their quest to repeat as Super Bowl champions on Sunday at Lincoln Financial Field against the San Francisco 49ers.

Here’s everything you need to know ahead of their wild-card matchup.

Eagles vs. Niners will kick off on Fox at 4:30 p.m. ET. Kevin Burkhardt and Tom Brady will call the game from the booth, and Erin Andrews and Tom Rinaldi will be on the sidelines.

If you’d rather listen to Merrill Reese and Mike Quick call the game, the radio broadcast can be found on 94.1 WIP, and if you’re not heading to the Linc, but want to watch the game with your fellow Birds fans, here are a few spots to check out.

» READ MORE: Eagles’ postseason adjustments, concerns with the offense, breakout players, and other AMA highlights

There will be six games played over the next three days. Here’s the full playoff schedule for the wild-card round …

NFC

AFC

First, the Birds need to take care of business on Sunday, but if they do, they could face one of three potential remaining NFC teams: the Los Angeles Rams, the Carolina Panthers, or the Chicago Bears. They could not, however, face the Seattle Seahawks or Green Bay Packers.

The lowest advancing seed will play the top-seeded Seahawks in Seattle. And because the Panthers and Rams — the No. 4 and No. 5 seeds, respectively — play one another, a team with a lower seed than the Eagles is guaranteed to advance. The Packers (or Niners, if they beat the Eagles) could also be in that spot.

If the Packers beat the Bears, Green Bay would be the lowest remaining seed and would face Seattle. The Eagles would then play the winner of the Panthers-Ram game, and would get to host that team in the divisional round. However, if the Bears win, the Eagles would travel to Chicago for the divisional round, with the Panthers-Rams winner heading to Seattle.

Because the Eagles-Niners game is the final NFC wild-card matchup, the winner won’t have to wait to find out its opponent.

It sounds like the Eagles won’t know until Sunday whether or not right tackle Lane Johnson, who has been out since Week 11 with a Lisfranc (foot) injury, will make his return to the offensive line. Johnson, interior lineman Brett Toth (concussion), and outside linebacker Azeez Ojulari (hamstring) are all listed as questionable for the Birds’ wild-card game. Ojulari was the only of the three who practiced fully on Friday. Johnson and Toth were limited all week.

On the flip side, the Eagles will be getting several banged-up players back in time for the playoffs. Defensive tackle Jalen Carter (hip), linebacker Nakobe Dean (hamstring), edge rusher Jaelan Phillips (ankle), tight end Dallas Goedert (knee), and safety Marcus Epps (concussion) were all full participants in Friday’s practice and are expected to play.

» READ MORE: Eagles officially list Lane Johnson as questionable for wild-card round

Meanwhile the 49ers have quite a few injuries, including to several starters. Veteran tackle Trent Williams, linebackers Dee Winters and Luke Gifford — after the team put LB Tatum Bethune on IR earlier this week — and cornerback Renardo Green are among those listed on the injury report for Sunday’s game. The following players are all questionable:

The Birds are a 5.5-point favorite at DraftKings and a 4.5-point favorite at FanDuel as of Friday afternoon. The over/under on both sites is set at 44.5.

As for the Super Bowl, the Seahawks are the betting favorite to win it all. At FanDuel, the Eagles have the fourth-best odds, at +800, behind Seattle, the Rams, and the Broncos. At DraftKings, the Eagles have the fifth-best odds, at +950, also behind the Patriots.

For more betting lines, click here.

What is the state of the Eagles’ offense? With Johnson potentially set to make his first start since Nov. 16 against the Detroit Lions, the banged-up offensive line could get a big boost.

In the starting offense’s final game of the year in Buffalo, they played one of their best first halves and worst second halves of the year. Which version will show up at the Linc on Sunday? And what will that mean for the future of offensive coordinator Kevin Patullo?

More storylines to watch:

5 — The total number of No. 3 seeds who have reached the Super Bowl since seeding was introduced in 1975.

» READ MORE: Eagles vs. 49ers: These numbers and trends could impact Sunday’s result

Here’s how our writers are predicting Sunday’s game …

Jeff McLane: “There’s a push when it comes to the Eagles’ underperforming offense vs. the 49ers’ subpar defense; but I give the edge to a great Eagles defense over a very good, but not great 49ers offense.” | Eagles 23, Niners 17.

Jeff Neiburg: “It hasn’t been an encouraging season from the Eagles’ offense, to put it mildly, but the 49ers are down multiple linebackers and don’t have an abundance of talent in the secondary. If the Eagles don’t beat themselves, which you can’t rule out, they should be able to establish a running game that gets the offense back on track.” | Eagles 24, Niners 20.

Olivia Reiner: “Maybe the Eagles can finish what the Seahawks started last week and continue to punish the 49ers on the ground. Maybe Jalen Hurts and the passing attack can exploit the 49ers’ thin inside linebacker corps with passes over the middle of the field. Neither have been characteristic of the offense this season, though. Or, maybe, the defense will stifle Shanahan’s offense while Nick Sirianni, Kevin Patullo, and the Eagles offense do just enough to get by. It wouldn’t be the first time.” | Eagles 24, Niners 20.

Matt Breen: “The Niners had a great finish to the season before their dud against the Seahawks, but they just seem too banged up to hang with the Eagles.” | Eagles 24, Niners 13.

» READ MORE: Jeff McLane’s keys to Eagles vs. 49ers in the wild-card round

The national media is divided over this one, but there’s a definitely lean toward the home team. Here’s a look at how they are predicting Sunday’s game …

Our columnists had plenty to say about the Eagles this week, including Mike Sielski, who believes their toughest opponent is not any team in the bracket, but themselves.

“From Eagles fans to the players themselves, there has seemed to be an ever-present blanket of expectations weighing on them. It’s as if the only thing that would make anyone happy and relieved at any moment this season would be another Super Bowl victory — a benchmark so lofty that it virtually guarantees people will be worried at best and miserable at worst unless the Eagles win every game 49-0."

Here’s more from our columnists …

David Murphy: “The pertinent question for Kevin Patullo and the Eagles now is what the offense will look like moving forward. This is a weird time of year. Sunday’s wild-card game against the 49ers could be the start of a month of football that leaves us memory-holing our four months of angst. Or, it could be the start of the offseason, and a litany of questions that sound way closer to January 2024 than January 2025.”

» READ MORE: What we know (and don’t) about the Eagles entering the wild-card round vs. the 49ers

Marcus Hayes: “It was Zack Baun. The best linebacker in football over the last two seasons. The man tasked Sunday with covering and tackling Christian McCaffrey, the best offensive player in football, and George Kittle, the league’s best tight end. In a city that still worships linebackers like Chuck Bednarik, Seth Joyner, and Bill Bergey, Baun somehow remains largely anonymous.”

Mike Sielski: “There’s more than one way to be an excellent head coach, even if one of those ways gets a little more attention, a little more scrutiny, a little more credit these days. The film can tell you how good a coach Kyle Shanahan is. What Nick Sirianni does well sometimes isn’t so easy to see. Come Sunday, may the best savant win.”

Kyle Shanahan is one of Vic Fangio’s biggest fans. Shanahan is such a big fan, that he’s tried to hire Fangio in San Francisco “all the times that there’s been an opportunity.”

“I mean, Vic schematically, he has always been the best to me,” Shanahan said. “As good as anyone there is. Has a very sound scheme that he doesn’t need to change up very much. It just naturally changes with how he does his coverages, how he does his fronts, the personnel groupings he does. He’s very good at getting a bead on what you’re trying to do and making you adjust.”

» READ MORE: 49ers coach Kyle Shanahan has ‘always respected’ Eagles defensive coordinator Vic Fangio

Sunday should be an extremely hostile environment for the Niners. Tight end George Kittle recalled a few of his craziest stories on Thursday.

“I just thoroughly enjoy it because it’s so unique every single time,” Kittle said. “I’ll never forget my rookie season, the year they won the Super Bowl, it was my first time playing in the Linc. There were like four 10-year-old kids holding a seven-foot tall papier-mâché middle finger that had a rotating thing on it that made the middle finger come up. That was the coolest thing, I’ll never forget it. That was my rookie year and I was like this is excellent.”

Kittle isn’t the only member of the 49ers offense looking forward to playing in the Linc. Kyle Juszczyk is also ready to take on Eagles fans.

“It’s more difficult [going into a hostile environment] but the payoff is better,” Juszczyk told reporters. “There’s nothing like that feeling of going into a hostile territory and getting a win. Yeah, it’s a little bit more difficult, but it’ll be worth it in the end.”

» READ MORE: The 49ers know the Eagles — and their fans — but downplay history in Philly: ‘They hate all of us equally’

Listen to the latest episode

A common refrain from the NovaCare Complex during the Eagles’ up-and-down 2025 regular season has been that finding ways to win, regardless of style or circumstance, is the team’s greatest strength. Based on the group’s track record, especially the past two years, the claim would be hard to dismiss. The Eagles’ belief in themselves, however, will be put to the test this weekend, when the playoffs begin Sunday with a wild-card matchup against the San Francisco 49ers at Lincoln Financial Field. The Eagles might not be entering the postseason looking like the world-beaters that romped in last year’s Super Bowl, but that doesn’t mean they aren’t capable of pulling off another title run. The Inquirer’s Jeff McLane shares his reasons for hope and doubt for the possibility of a repeat. Listen here.

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